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Under the induction of oxidative stress, a part of HIF-1 is translocated to mitochondria, where it inhibits the respiratory chain by lowering the expression of mtDNA-encoded mRNA that responses to hypoxia, thus preventing the over-production of ROS and resisting oxidative stress

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Neurite outgrowth in PC12 cells stimulated by acetyl-L-carnitine arginine amide

it's addressing the underlying cellular imbalances that contribute to acne

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