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Their work, published in peer-reviewed journals, demonstrated that blocking this enzyme could produce significant changes in body composition without affecting food intake

Instead, the authors showed that hyperosmotic shock leads to breakdown of sphingomyelin, accumulation of ceramide, and later on to PS exposure and cell shrinkage

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Advanced in vitro models To bypass the limitations of 2D cultures, advanced in vitro culture systems have been developed, including the use of 3D organized structures, known as organoids, and kidney microphysiological systems (MPS) that can recreate fluidic characteristics found in vivo (Fig