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Published binding studies have demonstrated 10-100 fold increased potency compared to native alpha-MSH at the MC1R

A 0.25 mg dose is 0.1 mL, which equals 10 units on a U-100 syringe

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found that histidine catabolism affects the sensitivity of cells to methotrexate, and dietary supplementation of histidine maintains a suitable chemotherapy effect with a low dose of medication

Scientific References Sikiric P