Among the CXC ELR + chemokines, especially CXCL8 has been found to be important for tumor angiogenesis in several tumor types [198, 199]
Rare side effects: itching, exanthema, chills, fever, hot flushes, nausea, dizziness, and very rarely anaphylaxis
Because tumor growth also depends on new blood vessels, several reviews describe this as a theoretical concern that has not been resolved in humans (Sehgal et al., Pharmaceuticals, 2025)
Some countries allow medical use under supervision
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How it was discovered: Scientists studying stomach ulcers noticed a particular protein sequence that protected the gut lining