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Because the schedule is weekly rather than daily, it is easy for people to occasionally forget a dose especially during travel, busy weeks or schedule changes

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A 2001 RCT by Nusgens and colleagues published in the Journal of Investigative Dermatology (N=33) used punch biopsy to demonstrate that topical vitamin C significantly increases mRNA levels of collagen I, collagen III, and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the human dermis direct molecular evidence of collagen gene upregulation at the tissue level

Do not take two doses together to make up for the missed one

Apply a small amount evenly to face and neck

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