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Administration of Sch B significantly inhibits glycogen synthase kinase 3 (GSK3) activation in the hippocampus and cortex neurons of triple-transgenic Alzheimers disease (3 Tg AD) mice, upregulates Nrf2, GPX4, and ferroptosis suppressor protein 1 (FSP1) expression, reduces levels of MDA, Fe 2+ , ROS, and tumor necrosis factor alpha (TNF-), thereby suppressing neuronal ferroptosis and neuroinflammation and improving learning and memory performance

167 B Vitamins Niacin (vitamin B3) is one of the more effective agents for raising high-density lipoprotein (HDL)-cholesterol levels

Mar 2021;165:105413

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