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In a substudy of 178 patients from the SUSTAIN 8 trial on semaglutide as a diabetes treatment, the average proportion of lean mass loss was nearly identical at 40%, despite lower doses and less total weight loss than in the STEP 1 trial

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But falling below your caloric threshold (often cited as below 1,200 calories/day for women and 1,500 for men, though individual thresholds vary) needed to support basic function and lean mass preservation may work against you and accelerate muscle loss