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Mar 2021;10(3):1410-1431

Rate constants for mammalian glutaredoxins and poplar GrxS12 range from 2.5 10 4 to 2 10 6 M 1 s 1 and also support a rate-limiting reductive half-reaction 19,20,21,37

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According to the recently completed ELIXA and LEADER trials, an increase in HR, regardless of its magnitude, does not appear to increase the cardiovascular risk of individuals with T2DM and with (or at high risk of) cardiovascular disease