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More importantly, most existing pharmacologic approaches target isolated pathogenic pathwayssuch as oxidative stress or inflammationwithout addressing the multifactorial nature of RIRI, which involves a complex interplay of mitochondrial dysfunction, immune activation, endothelial injury, and programmed cell death [5]
10.1016/j.jep.2012.03.013 101 HaJ.-H.LeeD.-U.LeeJ.-T.KimJ.-S.YongC.-S.KimJ.-A.et al (2000)
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