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PubMed Randomized trialTirzepatide evidence2025 Tirzepatide for Obesity Treatment and Diabetes Prevention Supports newer discussion of obesity treatment and diabetes-prevention outcomes

Oxidative stress impairs endothelial function, and glutathione's antioxidant properties may help protect against this oxidative damage

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Next-generation agents include CagriSema (semaglutide + cagrilintide, NDA filed December 2025, showing 22.7% weight loss), retatrutide (triple GIP/GLP-1/glucagon agonist, 28.7% weight loss in Phase 3), and orforglipron (oral non-peptide GLP-1, submitted to FDA)