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These effects are mediated by the upregulation of TP53, CASP3 and CASP8 genes and the reduction in BCL-2, NRAS and KRAS genes

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It demonstrated that longer-acting GLP-1 analogs could be even better since exenatide was short-acting, the obvious next step was to extend its action to once-daily or once-weekly to provide more consistent glucose control

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Updated 25 August 2017

These signaling pathways have different physiological functions from cAMP in glucose-stimulated insulin secretion