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Notably, nanomedicine or delivery-based approaches are also being explored to co-administer ferroptosis-inducing drugs with FSP1 inhibitors, highlighting a practical path for improving tumor-selective exposure and therapeutic index in vivo 123

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Among these, SLC7A11 stands out as the primary functional subunit, orchestrating the pivotal role of transporting cystine into the cell [18]

doi: 10.1016/j.intimp.2014.01.017 84 MetwallyDMAl-OlayanEMAlanaziMAlzahranySBSemlaliA