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When they administered semaglutide to lab animals, the c-Fos distribution indicated that a number of brain regions were being indirectly activated by the GLP-1R agonist that had not shown up as being directly activated (Gabery et al., 2020)

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While this risk has not been confirmed in humans, it remains a concern for individuals with a personal or family history of thyroid disease

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In addition, COX-2, which is encoded by prostaglandin-endoperoxide synthase (PTGS2), converts AA to multiple prostaglandins, including prostaglandin E2 (PGE2), which is also involved in inflammation