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2 h An 8-week dose-escalation regimen was used, with dose escalation from 0.25 mg per week for 4 weeks then 0.5 mg per week for another 4 weeks, followed by maintenance dose of 1 mg per week throughout remainder of the treatment period
Lose too much muscle and your metabolism drops, your functional capacity declines, and long-term weight maintenance becomes nearly impossible
This imbalance can further exacerbate cognitive and behavioral challenges, such as difficulties with learning, memory, and behavior control, making brain function more vulnerable to disruptions
It is worth noting that Wegovy itself carries a low intrinsic risk of hypoglycaemia when used as monotherapy in patients without diabetes, as its glucose-lowering effects are glucose-dependent
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The reasons are multifactorial: chronic inflammation damages blood vessel walls, corticosteroid use raises cholesterol and blood pressure, lupus-specific antibodies (particularly antiphospholipid antibodies) increase clotting risk, and the metabolic disruption caused by both the disease and its treatments creates a perfect storm for atherosclerosis
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