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PKF275-055 treatment restored mechanical sensitivity thresholds by approximately 50% and progressively improved the alteration in thermal responsiveness in diabetic rats, which was possibly mediated by counteracting the alterations in Na/K-ATPase activity and nerve conduction velocity [87]
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& Jensen, K
With tolerable safety, favorable effects on cardiometabolic risk, and alignment with patients preferred outcomes, it raises the bar for obesity treatment
however, the clinical relevance of this finding in humans is uncertain, and this is not listed as a contraindication in UK or EU Summaries of Product Characteristics for licensed medicines in this class
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