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To further validate the multivalent interactions of D-CuP, SPR analysis was performed to quantify its binding ability to p53 and HDAC7 in comparison with M-CuP

Intriguingly, our data suggest that AP2, a critical transcription factor in PGC specification, might be responsible for the recruitment of the TRIM37TRIM28 repressor complex to downstream target loci in migrating PGCs

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Furthermore, the design presents a promising approach for leveraging bioactive linear peptides