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(2000) NCBI (accessed 26 October 2021) Utovlan 5 mg Tablets (2018) EMC (accessed 26 October 2021)

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Research started with animal models, which established its safety to the point that human trials got started, too

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Most practitioners recommend starting at 250-300 mcg daily to assess tolerance, then potentially increasing to 400-500 mcg if initial response is suboptimal and no side effects occur