medullary thyroid cancer and glp 1 GLP-1 Receptor Agonists Risk, Rodent Data and FDA Warning, • In rodents, GLP-1 receptor agonists (GLP-1 RAs) stimulate thyroid C-cells, increasing the incidence of thyroid tirzepatide medullary thyroid cancer survivor

doi: 10.1016/j.cellsig.2024.111282 96 SunHSunZVargheseZGuoYMoorheadJFUnwinRJet al

Most weight management medications approved by the FDA are for adults

Others may not see a significant change if their nausea has already resolved through adaptation

Weight of evidence: Overall evidence is Moderate : pediatric trials show lipid-peroxidation reduction and improved antioxidant status, with mixed behavioral effects

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Safety and Tolerability of Glucagon-Like Peptide-1 Receptor Agonists: A State-of-the-Art Narrative Review