According to available research, weight loss on metformin does occur, though the medication likely wont produce dramatic results
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NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction
Cell cultures were supplemented with IGF-1 (10, 50, and 100 ng/mL), and the results showed that cell proliferation was more significant in all cell types after IGF-1 stimulation compared to the control group (received no IGF-1)
Therefore, we concluded that inhibition of GSDMD-mediated pyroptosis in macrophages weakened endothelial function and angiogenesis