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Chemical Instability: Over time, the active ingredients in compounded medications may degrade, leading to unpredictable results
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Some portion of intranasally administered peptides may reach the brain through the olfactory pathway, bypassing the blood-brain barrier that limits systemic delivery to CNS tissues
Overall, there is a clear need for improved exposure assessment methods, establishment of evidence-based regulatory thresholds, and internationally coordinated monitoring efforts to better evaluate the health risks associated with REE exposure
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