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Approaches include redox interactions with high-valent metal ions (like Cu 2 and Fe 3 ), suppression of GSH synthesis using agents such as BSO, the use of nanozymes that mimic enzymatic activity, and direct GSH neutralization through molecular binding [18]

3.3 Necroptosis Necroptosis is a programmed cell death response to a specific environmental signal, morphologically resembling necrosis

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Selenium in a double pack Glutathione relies on selenium to fulfill its role as a free radical scavenger