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After 68 weeks of treatment with semaglutide 2.4 mg (the Wegovy dose, identical to the molecule in Ozempic), participants lost an average of 14.9% of their body weight
Severely restricting food intake creates nutrient deficiencies, energy crashes, and paradoxical hunger signals that undermine your treatment
While the preservative system in semaglutide formulations provides antimicrobial protection, this protection may diminish over extended periods, potentially allowing bacterial contamination
For example, a patient with obesity starting a GLP-1 medication who also has a personal history of DVT and takes oral contraceptives carries substantially higher baseline risk than someone with obesity alone
However, recent insights suggest that the gut and brain GLP-1 systems operate largely independently with mRNA transcripts for proglucagon (GCG), the precursor peptide for GLP-1, being abundant in the brainstem, particularly within the nucleus tractus solitarius (NTS
We might schedule IV drips
