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Pillar 1: Activity (aerobic + resistance + daily movement) Physical activity improves insulin sensitivity through several mechanisms at once: increased glucose uptake (including non-insulin-mediated uptake), improved muscle insulin signalling, reduced intramuscular lipid burden (DAGs), improved hepatic insulin sensitivity, and improved appetite regulation via brain signalling

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doi: 10.1038/s41467-022-32260-w 232 OkahashiN.SumitomoT.NakataM.SakuraiA.KuwataH.KawabataS