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Data Animal Data In pregnant rats given twice weekly subcutaneous doses of 0.02, 0.1, and 0.5 mg/kg tirzepatide (0.03-, 0.07-, and 0.5-fold the MRHD of 15 mg once weekly based on AUC) during organogenesis, increased incidences of external, visceral, and skeletal malformations, increased incidences of visceral and skeletal developmental variations, and decreased fetal weights coincided with pharmacologically-mediated reductions in maternal body weights and food consumption at 0.5 mg/kg

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Figure 8) investigated in 14 human exposure scenarios, it was possible to correctly separate their risk classification by using the lowest BER per readout and lung model

doi: 10.1016/j.bbrc.2022.01.106 201 MuriJ.KopfM