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Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke

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Fluvastatin, lovastatin, pravastatin, and simvastatin have short half-lives ( 100 times the upper limit of normal), along with myoglobinuria and acute kidney injury due to myoglobin-induced tubular necrosis (Bosch et al

It concentrates its effects near the administration site, promoting collagen synthesis, reducing local inflammation, and stimulating growth factors directly in damaged tissue