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Stem cell niches may reactivate in cleared tissue Months 1-6+: Gradual tissue remodeling and functional recovery in organs where senescent cell burden was reduced This cascade explains why FOXO4-DRI doesn't produce immediate, obvious effects

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doi: 10.1016/j.ejogrb.2011.07.005 146 DubeyPReddySBoydSBracamontesCSanchezSChattopadhyayMet al

It may help reduce cognitive fog, mental fatigue, and motivation dips linked to estrogen decline

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