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This metabolic change is likely linked to the chronic inflammation characteristic of RA, creating a potential cycle where inflammation and metabolic issues feed into each other

dosing with 100 nmol kg 1 MK-801, 100 nmol kg 1 GLP-1, 100 nmol kg 1 GLP-1MK-801 or vehicle

42: 5837 Rebouche CJ, Paulson DJ

For mitochondrial activity, the cells were incubated with 200 mM MitoTracker Deep Red (Thermo Fisher Scientific, Barcelona, Spain) for 20 min at 38.5 C in the dark and then stained with 10 M YO-PRO-1 and 0.5 M PI

Paez PL, Becerra MC, Albesa I

Glutathione protects cells from oxidative damage while NAD+ provides the energy for cellular function