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Tissue Inhibitor of Metalloproteinase (TIMP) Interactions The balance between MMPs and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), determines net proteolytic activity in tissues

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More potent and longer-lasting than the naturally occurring IGF-1 released by the liver

40 In a mouse model, IL-12 was shown to be protective against thicker plaques, therefore inhibition may be counterproductive