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Understanding the Study Timeline: Phase 2a vs Phase 3 Phase 2a MASLD Substudy (2023) - SOURCE OF 86% RESOLUTION DATA Status: COMPLETED and published Study Design: Part of larger Phase 2 obesity trial (NEJM 2023) Focused substudy on patients with MASLD Liver fat measured by MRI-PDFF (gold standard) Duration: 48 weeks Published results available This is where the 82.4% liver fat reduction and 86% resolution rate data comes from
doi: 10.1093/ajcn/61.2.296 41 BryantMTruesdaleKPDyeL
The overall three-year risk of first-time AD diagnosis was almost two-fold higher in the general older population
Discard the injection pens carefully after use
The potential cost of skewed data far outweighs the cost of reconstituting a fresh vial
The key question plan sponsors should ask is how much money the PBM makes by approving a higher-cost drug
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