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Memory impairment has been reported with acetazolamide use [30], additionally several studies have identified impairments in language, working memory [31, 32], verbal fluency [32], Intelligence quotient, and verbal learning [21]
Meta-analyses show mean differences in HbA1c reductions versus placebo of 1.4% to 0.5% [20, 22, 24,25,26,27]
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This restricts our ability to elucidate the mechanisms underlying the observed mortality reduction associated with combination therapy
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It appears to shorten the inflammation phase
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