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doi: 10.1016/j.medcle.2017.03.003 445 BaimakhanovaBSadanovATrenozhnikovaLBalgimbaevaABaimakhanovaGOrasymbetSet al

Upadhyay et al ., showed that ibuprofen induced proteasome dysfunction, mitochondrial-mediated apoptosis, and cell death in A549 and/or Cos-7 cells 38

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Strong and stable inhibitory activity was observed in 4-[4-(hydroxyphenyl) prolyl] prolinenitriles, which demonstrated a long duration of action