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Biguanides, once responsible for more than 35% of prescriptions, have steadily lost share as patients and providers increasingly turn to GLP1s
Common factors include weighing less than 110 pounds, low hemoglobin levels from nutritional deficiencies, dehydration from medication side effects, or unstable blood pressure
Chang H-H, Chen B-Y, Wu C-Y, Tsao Z-J, Chen Y-Y, Chang C-P, et al
Diabetologia 66(6):9861002
BMI Outcomes: Crossing the Obesity Threshold 65.3% of patients on the 12mg dose dropped their BMI below 30 moving from the "obese" to the "overweight" or "normal" BMI category
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