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FHI-HADH, caused by mutations in HADH, tends to be relatively mild, although severe cases have been reported
D.UssherJ
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Once a vial has been punctured, it should be discarded after 28 days even if liquid remains, since preservative effectiveness gradually decreases with repeated punctures and air exposure
Further, since this was an investigation focused a priori on S-5-HT levels, it remains unknown if the effects were specific to serotonin synthesis, or if other pathways were also affected
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