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The expression levels of NRF2 were evaluated using the Human Protein Atlas portal website ( and the Gene Expression Omnibus (GEO), GSE119087, database
This approach may be particularly valuable in studies examining how different signaling systems overlap during regeneration and structural remodeling
Considering the positive impact of Nrf2 in ameliorating oxidative stress, a number of bioactive components that exert protective effect against APAP-associated hepatotoxicity have been identified and reported, including caffeic acid that activates the Keap1-Nrf2 antioxidant defense system (Pang et al., 2016), carnosic acid that promotes nuclear translocation of Nrf2 ( via AMP-activated kinase/Akt/glycogen synthase kinase 3 pathway (Wang et al., 2016)
Upon mitochondrial damage, PTEN-induced kinase 1 (PINK1) accumulates on the outer mitochondrial membrane, recruiting the E3 ubiquitin ligase parkin [26]
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