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There is a risk of mild diarrhoea, upset stomach, nausea, a feeling of pain and warm sensation at the site of the injection, a feeling or a sense of being swollen over the entire body, headache and joint pain

In 2011 a phase II randomized study was conducted in Germany to evaluate the efficacy and safety of two dosage regimens of subcutaneous bioresorbable afamelanotide implants in patients with mild to moderate acne vulgaris [10]

A 2006 paper in In Vivo characterised that the synthetic pineal peptide suppressed spontaneous carcinogenesis in animal models (PMID 16634527)

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