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Effect is more pronounced when both compounds are at maintenance

In heterodimeric GST complexes such as those formed by the cytosolic mu and alpha classes, however, the cleft between the two subunits is home to an additional high-affinity nonsubstrate xenobiotic binding site, which may account for the enzymes' ability to form heterodimers

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As mentioned earlier, under normal conditions it contributes to a wide range of plant processes, e.g., chloroplast redox reactions, photosynthesis, seed germination, floral induction, fruit expansion, cellular ROS regulation, oxidative defense system, membrane stability, plant water status and senescence etc

OASIS trials: establishing effective doses Phase 2 OASIS 1 findings: Tested multiple dose levels: 0.3mg, 0.6mg, 1.2mg, 2.4mg, 4.5mg weekly Duration: 26 weeks Primary endpoint: Weight loss at each dose Dose-response results: 0.3mg weekly: ~4% body weight loss 0.6mg weekly: ~6% body weight loss 1.2mg weekly: ~8% body weight loss 2.4mg weekly: ~10% body weight loss 4.5mg weekly: ~12% body weight loss Key insight: Clear dose-response relationship

Indication expansion, such as approvals for additional metabolic and cardiovascular conditions, is broadening patient access and driving adoption