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And it's a series of studies with different designs and populations to look, in randomized controlled trials that's the highest level evidence at what this drug would do for individuals with obesity, individuals with obesity who also had diabetes, what about if we add intensive lifestyle therapy to it, what would happen if we stopped the medication, what about individuals living with arthritis or with heart failure or heart disease

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Given the current lack of robust evidence from long-term, large-sample RCTs, the majority of evidence for pharmacological interventions targeting MC4R -deficient obesity discussed in this review - particularly for liraglutide and semaglutide - derives from case reports

Rodriguez-Flores EA, et al

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High-volume, lower-calorie foods