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[47] reported similar findings, showing that the AMPK activator metformin increased LDLR expression in HepG2 cells through both SREBP-2-dependent and independent mechanisms
Given the limitations of imaging and intraoperative pathology in detecting early metastasis, close postoperative surveillance is critical
doi: 10.1096/fj.201801397R 52 FengHJBotzolakisEJMacdonaldRL
Absolute contraindications Medullary thyroid cancer MEN-2 Pregnancy or breastfeeding Prior severe allergic reaction to GLP-1 medications Conditions requiring extra caution Gastroparesis or delayed gastric emptying History of pancreatitis Advanced diabetic retinopathy Use alongside medications that increase hypoglycemia risk These and a few other situations require individualized assessment, which is why specialty endocrine care matters
L., & Schifano, F
59 These findings suggest that vesicle-mediated signaling may either amplify or restrain ferroptosis depending on cargo composition and uptake efficiency, highlighting extracellular vesicles as bidirectional regulators of ferroptotic susceptibility rather than unidirectional death signals
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