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Potential of these effects may be heightened in patients with breast cancer treated with hepatically metabolized chemotherapeutics (e.g., cyclophosphamide, paclitaxel, anthracyclines) or tyrosine kinase inhibitors in which drug-drug interaction-based elevation or lowering of enzyme activity can result in supra-therapeutic drug concentrations, accumulation of toxic metabolites and compromised detoxification of reactive oxygen species facilitating hepatocellular distress

i , Autochthonous tumors from MMTV-PyMT Gclcf/f Rosa26-CreERT2 mice were excised and orthotopically transplanted into the mammary gland or subcutaneously transplanted into the flank of wild-type C57BL/6 mice, which were treated with vehicle (corn oil

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Comparison of copper-bound GHK with metal-free GHK

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Then, 10 L of propidium iodide were added and the cells were further incubated for 10 min