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Behavioural factors play an equally important role

This combined approach results in improved glycemic control and substantial weight reduction, with clinical trials demonstrating HbA1c reductions of 1.9% to 2.4% and weight loss of approximately 15% to 22% of body weight at the highest doses in specific trials such as SURMOUNT-1

Side effects track dose increases, not the absolute dose, and they improve on a stable dose

Gastric sleeve surgery is one of several types of bariatric surgery options

But GLP-1 was quickly chewed up in the blood by enzymes, and giving diabetic participants large doses of it made them throw up

In this way, it serves as a proofofconcept that even a peptide or protein drug known to have poor bioavailability can still be delivered orally, and without any modification, if we compensate by delivering a sufficiently high dose