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They do not replace proper GLP-1 technique but can address secondary concerns like gut health , hair preservation , and energy levels that sometimes become issues during aggressive weight loss protocols

Front Endocrinol (Lausanne) 15:1330629

These include the severity of deficiency, medical conditions, age, and weight

See the Retatrutide protocol page for the standalone reference

In the landmark SELECT trial in 2023, the scope of GLP-1RAs was expanded to assess cardiovascular risk in patients with preexisting cardiovascular disease who were overweight or obese without type 2 diabetes [48]

Total cholesterol and LDL cholesterol levels decreased in both groups