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Both are once-weekly injections from Eli Lilly, but retatrutide adds a third hormone receptor (glucagon) on top of the GLP-1 and GIP receptors that tirzepatide already targets
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By activating GLP-1 receptors, Semaglutide GLP-1 enhances the bodys response to food, leading to increased insulin secretion
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For years now, GLP-1s have had a more is more reputation
It combines the effects of GLP-1 agonism with those of GIP, potentially offering additional benefits: - Enhanced insulin secretion and sensitivity - Greater appetite suppression - Improved lipid metabolism - Potential direct effects on adipose tissue[1] This dual action may explain why tirzepatide has shown superior efficacy in clinical trials, demonstrating greater reductions in HbA1c levels and body weight compared to existing therapies, including semaglutide[4]
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