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Fazeli PK, Horowitz MC, MacDougald OA, Scheller EL, Rodeheffer MS, Rosen CJ, et al

A few reasons: Energy support

For acute injuries with significant pain and swelling, some practitioners and experienced users suggest a higher loading approach during the first 3-5 days: 0.5 mg twice daily (1 mg total) before reducing to maintenance dosing

Of particular promise, nanoparticles can insulate their contents from external biochemical injury [11]

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Current research gaps include long-term safety data, optimal dosing protocols for different populations, and comprehensive efficacy studies in diverse patient groups