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Both weekly subcutaneous injections and the oral tablet form of semaglutide have been shown to be effective for weight loss

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It was also approved on January 18, 2025, for its effects in reducing kidney disease and cardiovascular risk in diabetic adults

Mazzocchi A, et al

Older oral anti-obesity agents phentermine-topiramate extended release, naltrexone-bupropion, orlistat have smaller mean effects but are often available at far lower cost, sometimes as generics