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Chen WB, Wang YX, Wang HG, An D, Sun D, Li P, Zhang T, Lu WG, Liu YQ (2023) Role of TPEN in amyloid- 25-35 -induced neuronal damage correlating with recovery of intracellular Zn 2+ and intracellular Ca 2+ overloading

Tests carried out on mice in order to determine LD50 as well as with the purpose of obtaining data about acute, sub chronic and chronic toxicity have been unsuccessful as this peptide applied intravenously or intraperitoneally in a broad dose range from 10 ng to 100 mg/kg of body weight, did not induce any toxic changes

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Oxidative stress can exacerbate these pathological features through several mechanisms