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Adults who are overweight (BMI 27 kg/m) and have at least one weight-related health condition (e.g., high blood pressure, type 2 diabetes, high cholesterol, obstructive sleep apnea)

Novo had also prioritized an experimental dual-acting injectable drug, only to see that therapy and another oral drug prospect generate disappointing study data

Wang et al., 2015)

Users who have achieved significant results may choose to continue at a maintenance dose, take a break and reassess, or adjust their protocol in consultation with a healthcare provider

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Three MARA domains are material: Clinical Effectiveness (exceptional efficacy, unresolved cardiovascular safety signal), Comparator Selection (retatrutide will be assessed against tirzepatide, not placebo), and HRQoL (higher side effect burden may narrow access relative to established alternatives)