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These effects have been demonstrated primarily in laboratory and small clinical studies

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Unlike prior studies of AMD development that were limited to patients with diabetes, the authors wrote in their paper, their findings suggest that GLP-1 drugs "may be associated with reduced risk even in individuals with obesity but not diabetes, potentially supporting a protective benefit independent of glycemic control and mitigating diabetes as a confounding factor.

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

doi:10.2337/db10-0474 114

The treatment was 1,000 g of cyanocobalamin (n=54), 1,000 g of cyanocobalamin plus 400 g of folate (n=51), and a placebo (n=57)