3,5 In early T2DM managed with lifestyle alone, orforglipron lowered glycated hemoglobin A1c (HbA1c) by -1.24 to -1.48 percentage points over 40 weeks as compared to -0.41 with placebo, with no severe hypoglycemia reported and weight reduction ranging from 4.5% to 7.6%, 3 which led to mean HbA1c levels of 6.5-6.7%
Id hoped this would be the magic thing that finally worked, she said
Balancing the Risks and Benefits In clinical practice, the potential for mild digestive discomfort (including occasional heartburn) should always be weighed against the profound benefits Wegovy offers: Sustained, clinically meaningful weight loss: Patients in major studies achieved an average of around 15% reduction in body weight over 68 weeks, outperforming many other weight-management medications
Good experience, but the tracking updates could be better
They are about choosing the right tool, at the right time, for the right person
Though remarkably effective, bariatric surgery carries the limitations inherent to any invasive procedure (surgical complications, cost, access): it is hard to imagine tens of millions of obese individuals going under the knife each year
