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7 How GLP-1 drugs may reshape addiction pathways GLP-1 RAs interact with the mammalian mesolimbic reward system and have been proposed to modulate dopaminergic signaling in circuits involving the ventral tegmental area, nucleus accumbens, and other reward-related regions, thereby reducing the reinforcing value of food and some substances in preclinical models

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Abbreviations DPP-4: dipeptidylpeptidase-4 GLP-1: glucagon-like peptide-1 GIP: glucose-dependent insulinotropic peptide SU: sulfonylureas TZD: thiazolidinedione SDF-1: stromal-cell-derived factor-1 SGLT2: sodium-glucose co-transporter 2 ARB: angiotensin type 2 receptor blocker ACE: angiotensin converting enzyme TRAF3IP2: TRAF3 interacting protein2 MIP-1: macrophage inflammatory protein-1 Tregs: T regulatory cells SAVOR-TIMI: saxagliptin assessment of vascular outcomes recorded in patients with diabetes mellitus (SAVOR)thrombolysis in myocardial infarction (TIMI) TECOS: trial evaluating cardiovascular outcomes with sitagliptin EXAMINE: examination of cardiovascular outcomes with alogliptin versus standard of care References Khaw KT, Wareham N, Bingham S, Luben R, Welch A, Day N

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