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Mechanistic investigations revealed that PTX resistance was primarily mediated by EV-derived VDAC1 through the AMPK/mTOR pathway, which involved activation of general autophagy and mitophagy

Immunohistochemical analysis shown in Fig

At ~33.3 mg/mL, 1 unit 0.333 mg

In addition, the predictive performance of the final model was assessed by prediction-corrected visual predictive check (VPC) plots

For stable knockdown, HEK293 cells were seeded in six-well plates at a density of 4 10 5 cells per well 24 hours before transfection

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